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Functional analysis of the two TP53 variants in codon 72 showed that this polymorphism might modulate these two responses.

In future it will be important to determine whether Rit might modulate these, or other p38-dependent processes.

There is an interesting possibility that requirement of insulin in certain tissues for the entry of glucose might modulate these effects such that different tissues are differently affected [ 42].

In addition, analysing the characteristics of caregivers and/or patients that might modulate these attitudes, the results show that mothers were the caregivers with the most negative attitude towards schizophrenia.

As increased levels of extracellular proteases such as uPA and matrix metalloproteinases (MMPs) have a strong correlation with glioma cell motility and invasion (Gladson et al. 1995, Forsyth et al. 1998), we postulated that anosmin-1 might modulate these proteases.

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The present study showed that the EBR system decreased the CD11b expression and intracellular free calcium level of peripheral blood neutrophils compared with the sham treatment, which might modulate the activation of these neutrophils.

Although we cannot exclude that Agrobacterium-derived factors might modulate the induction of these processes to some extent, the fact that we were able to mimic the infiltration of tzs harbouring bacteria with hormone solutions shows that other bacteria-derived factors are not essential to induce the observed reactions.

On the other hand, based on the increasing evidence documenting co-occurrence of mutations in functionally related genes that contribute to the severity of the phenotype [Longoni et al., 2010; Nystrom et al., 2009; Tang et al., 2009; Thiel et al., 2009], the possibility that mutations concomitant to those affecting SOS1 might modulate the phenotype in these subjects cannot be ruled out.

Considering that dysregulation in DNA, methylation has been suggested as one relevant epigenetic mechanism in type 2 diabetes [ 41] and that both the FTO[ 42] and the MC4R[ 43] genes are regulated by methylation, the MedDiet might modulate the effect of these genes through epigenetic mechanisms.

Since binding of 6AP and GA to the ribosome is RNA-dependent and exhibits no inhibitory effect on protein synthesis, we wondered if these drugs might modulate the protein folding activity of the ribosome.

Overexpression or silencing of these CPKs might modulate the resistance to E. amylovora infection.

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