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These clinical data provided strong evidence that WNT5B might modulate mitochondrial physiology through MCL1, which was mediated by WNT/β-catenin pathway target gene, Myc.
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Finally, strategies to limit the extent of renal mitochondrial damage during hyperglycemia (by therapeutic agents that will specifically modulate mitochondrial function) might prevent or inhibit the development of nephropathy in the diabetic population.
Aon, M. A. et al. Glutathione/thioredoxin systems modulate mitochondrial H2 O2 emission: An experimental-computational study.
An alternative strategy, whose feasibility is supported by increasing experimental evidence, is to modulate mitochondrial ROS production itself.
In their turn, superoxide flashes modulate mitochondrial function, as they cause mitochondrial depolarizations.
Other molecules variably modulate mitochondrial metabolism depending on dose and time of administration.
Data from yeast suggests that, directly or indirectly, MAPKs can modulate mitochondrial respiration and ROS production.
Diazepam has been shown to modulate mitochondrial activity in the brain tissues [ 30].
Also, there is evidence to suggest that glucocorticoids modulate mitochondrial transcription through GR activation [ 21].
The authors proposed that an unknown function of the G72 in modulating mitochondrial morphology might be responsible for the risk-conferring property of the gene.
Therefore, we hypothesized that ATRA might modulate NRF2 expression as well.
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