PA also binds to AtCP to modulate actin filaments.
This suggests that Akt can modulate actin assembly in other ways.
These results demonstrate that scapinin can modulate actin cytoskeleton structures and thereby enhance cell spreading and motility.
Bacterial toxins (including bacterial effector proteins) modulate actin dynamics by either directly targeting actin (e.g. actin ADP-ribosylating toxins) or by targeting Rho family proteins (e.g. glucosylating toxins or bacterial GEF or GAP proteins).
These results suggest that the EspM effectors modulate actin dynamics by activating the RhoA signalling pathway.
These results show that EPEC effectors modulate actin dynamics by temporal subverting the Rho GTPases and other actin polymerization pathways for the benefit of the adherent pathogen.
Taken together, these results suggest a possible relevance for acetylation in amebic virulence and that Aspirin through acetylation of important cellular proteins, such as actin, might modulate amebic functions.
Because human VASP is a weakly processive actin polymerase and Lpd can interact simultaneously with both VASP tetramers and actin filaments, we hypothesized that Lpd might modulate the processivity of VASP by both clustering tetramers and tethering them to actin filaments.
The recent purification of myosin 15 will allow its motility to be tested on different types of cross-linked actin filaments, and to examine how the N-terminal extension might modulate this activity (Bird et al., 2014; Hartman et al., 2011).
Therefore, we hypothesized that ATRA might modulate NRF2 expression as well.
