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These observations raise the possibility that GPRC6A, might mediate some of the actions of Oc in vivo and provide a molecular pathway linking bone and energy metabolism.
There is a possibility that 42°C heat shock for 3 hours may have additional effects on the siRNA treatment, which might mediate some of the observed biological effects (Table 2 and 3).
Although they lack the RNA-binding region and immunodominant core epitopes, the "mini-cores" seem to be important functional components of the HCV protein repertoire, as they might mediate some biological functions of core, such as binding to lipid droplets [43].
Therefore, we hypothesized that SXR activation might mediate some of the anti-proliferative effects of these compounds in breast cancer.
Our data on VLDL secretion and glucose uptake suggests that both insulin and PPARγ might mediate some of their functions via affecting the expression of ANGPTL3.
Thus, improvements in sleep quality might mediate some of the stress protective and health promoting effects found in the intervention group.
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Thus, the target cleavage positions were predominantly at around the 10th nucleotide from the 5' end of the miRNA, but some might mediate cleavage at other locations.
In summary, these data suggest that down-regulation of GR expression and binding might mediate steroid resistance in some patients with SLE.
First, TReg-cell function is considered contact-dependent yet it is not clear how some mechanisms might mediate their function in this manner (for example, cytokines).
Therefore, it appears reasonable to conceive the hypothesis that dysfunction in epigenetic regulatory mechanisms might mediate the neurogenic imbalances responsible for some neuropsychiatric conditions, such as depression.
Since GPCRs can harbor significant numbers of ordered water molecules and are predicted to contain even more, some aldehyde ORs might mediate aldehyde hydration themselves upon ligand binding.
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