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The different receptor subtypes might mediate different pathological pain conditions.
These phenotypic observations gave a first indication that MAPK and AKT might mediate different signaling downstream to the NGF-TrkA axis.
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In a few instances, the obscured face of the RA (PDB: 1LFD [ 116]) and elongin domains (PDB: 1VCB [ 117]) might mediate specific interactions suggesting that their adapter function might depend on using both faces to mediate different sets of specific interactions.
Do they mediate different forms of plasticity?
This might indicate greater physiological significance, although the situation is more complicated given that different [Ca2+]i elevations are known to be able to mediate different astrocytic physiological processes at the subcellular level (Shigetomi et al., 2008).
It was suggesting that the different C-type lectin in C. farreri might mediate immune response towards different pathogen through specific PAMPs recognition [22]-[25 [22]-[25
Aub also binds to a set of stable mRNAs and might mediate their regulation through a different mechanism.
Similarly, some of the newly identified binding sites might mediate regulation of nearby genes under different growth conditions than those in which the binding profile was monitored.
This implied that SFPQ might mediate the effects of other factors and play different regulatory roles.
Second, experiments directed towards defining the cis-acting DNA sequences at the CA9 and PHD3 loci that might mediate HIF-α isoform-selective responses yielded quite different results.
Whether mechanistically different interactions between Wnts and coreceptors might mediate signaling remains to be determined.
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CEO of Professional Science Editing for Scientists @ prosciediting.com