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In reality more than one environmental parameter might lead cells to differentiation [3], [6], [7], [23].
This reality might lead cells to rely more heavily on mitochondrial oxidative phosphorylation to produce energy (Aguer et al., 2011).
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To eliminate the possibility that injection of inside cells per se might lead to cell death, we injected inside cells with DxRed alone (n = 19 embryos).
Deregulation of fission and fusion proteins that control mitochondrial shape and number can impair cell functions and might lead to cell degeneration.
ATAD3A deficiency might lead to cell cycle arrest with polynuclear cells, finally causing apoptosis [8].
It is possible that the loss of GluR2 protein could lead to increased calcium influx into cells through AMPARs which might lead to cell death.
Induction of HSPs in cells already primed by inflammation might lead to cell death by apoptosis [ 48].
Wang et al. showed that these miRNAs suppress cervical (HeLa) cancer cell growth [ 11], suggesting that downregulation of miR-143 and miR-145 might lead to cell proliferation in CC.
Many reports were published on the internalization of GBNs as therapeutic agents as well as they might lead to cell intoxication [152].
Alteration in the epigenetic status might lead to cell death by restriction enzymes [19] [21].
However, if p53 is inactivated, chronic exposure to a low dose of microcystin-LR might lead to cell proliferation through activation of Akt signaling.
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CEO of Professional Science Editing for Scientists @ prosciediting.com