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Although a single Sgt1 molecule might interact simultaneously with both-N domains in an Hsp90 dimer, this is inconsistent with the ∼1 1 binding stoichiometry suggested by ITC (Supplementary Figure 1).
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Because human VASP is a weakly processive actin polymerase and Lpd can interact simultaneously with both VASP tetramers and actin filaments, we hypothesized that Lpd might modulate the processivity of VASP by both clustering tetramers and tethering them to actin filaments.
As it is shown, multiple chording areas are allowed and thus multiple users can interact simultaneously.
The sorbent composite was designed to interact simultaneously with higher metal loading by complexation-adsorption process.
These geometric features allow cholesterol to interact simultaneously with anandamide and with sphingolipids.
Lately, it has been shown that even genes from different chromosomes may interact simultaneously in one transcription factory [14], [15].
In addition it is not clear whether LI and CC could interact simultaneously with PB3.
Thus in theory, the Vps4-Vta1 couldex could interact simultaneously with 24 ESCRT-III subunits [62].
Additionally, previous FRET studies suggest that Gαq can interact simultaneously with Gβγ, B2R, and Cav1.
Therefore RACK1 is capable to interact simultaneously with several signaling molecules [ 8], suggesting the possibility of multiple protein interaction surfaces.
Because COS-5.44 and Fluconazole have different modes of action, we examined the effect of treating cells with both compounds simultaneously to test if these two compounds might interact synergistically.
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