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However, we and others have suggested that compulsive drug seeking in addiction might instead result from weak inhibitory control over a rather independently established, drug-influenced, maladaptive incentive habit (4,21).
In this case, restoration of papillomatous lesions in Involucrin-c-MycER TAM mice might instead result largely from the replication of 'c-Myc naïve' keratinocytes newly generated from the basal layer during the period of c-Myc inactivation [ 28].
As C73R does not give rise to a TNFR1 shedding defect [ 51], this led the authors to speculate that the C73R mutation might instead result in failure to retain the receptor within the Golgi [ 50], with the C73R mutation either masking a Golgi retention motif within this region or in an area of the molecule that is influenced by mutations in this region.
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Fitness tradeoffs between selfing and outcrossing might have instead resulted from developmental/ecological resource allocation constraints between male and female functions in hermaphrodites, despite males [ 51, 52].
Dr Formisano suggests that the methane might instead be the result of "pseudo-volcanic activity", such as the slow release of gas from volcanic fissures or geothermal vents.
Similarly, establishing that an observed phenotypic shift has a plastic basis does not confirm that the change is adaptive – it might instead be the result of environmental stress.
The simulations here showed that the faster proliferation of a more aggressive tumor with lower k cells did not necessarily lead to an overtly larger tumor but instead might result in earlier tissue invasion and metastasis.
This result might, instead, indicate that our effectiveness estimates of seasonal vaccines are driven by biases, in particular case selection biases.
To gage whether these results might instead be picking up cross-country (as opposed to firm-specific results), the probit regressions are rerun for separate samples of countries according to whether their collective agreement coverage is high or low.
A disadvantage might, instead, be imposed as a result of a general indifference toward the interests and rights of the members of a certain group.
Alternatively the C73R mutation might instead abolish a Golgi retrieval signal, resulting in failure to internalize TNFR1 and return it to the Golgi storage pool.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com