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Most of these are TGFβ target genes, suggesting that SMAR1 might inhibit cellular migration and invasion by modulating TGFβ signaling.
These results suggest that p53-R273H mightt minhibithibit cellular anoikis through suppression of BMF induction.
These results indicated that treatment of cells with cationic carriers might inhibit cellular Na+/K+-ATPase activity, thus causing intracellular Na+ overload and subsequent cell necrosis.
In most instances, the mode of action is through the cellular conversion of a precursor compound to an active triphosphorylated form that might inhibit cellular or viral DNA synthesis, interfere with nucleotide metabolism, or become incorporated as a toxic lesion into the DNA of rapidly dividing tumor cells.
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The finding that BAY 11-7082 nonlynly prevented the loading of ubiquitin on to Ubc13 and UbcH7, but also the conjugation of ubiquitin to many other E2 conjugating enzymes (Supplementary Figure S1) raised the possibility that it might inhibit every cellular ubiquitylation event.
Collectively, suppression of either VEGFR-2 or VEGFR-3 alone might not be sufficient to inhibit cellular signaling and lymphangiogenesis.
However, it has also been shown that chemical agents that block NGF TrkA interaction can inhibit cellular motility, leaving the possibility that these agents might be able to improve clinical prognosis of NGF-producing OESCC.
Thus, induction of MazF should inhibit cellular processes other than those protected from its action.
Researchers led by Da Jia at Sichuan University have now learned how these bacteria inhibit cellular trafficking by selectively interfering with the retromer-associated SNX5/SNX6 protein complex.
These antioxidants delay or inhibit cellular damage mainly through their free radical scavenging property [23].
Sub-lethal doses inhibit cellular respiration due to a nonspecific oxidizing effect (bactericidal effect) [36].
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