Our finding that siRNA knockdown of lamin A/C leads to impaired recruitment of 53BP1 to sites of DNA damage in U2OS cells when significant 53BP1 levels persisted (Figs 3F and S2C) implies that lamin A/C might influence DNA damage repair through two distinct mechanisms.
In terms of tumor growth for example, the presence (or local density) of distinct cancer cell subtypes might influence transitions between states of different proliferative potential [ 42].
Heterodimers may be considered as distinct structural and functional entities, which might influence drug affinity and efficacy.
Control group cohorts were studied to find out whether the time interval between the date of achieving a distinct ability and the interview date might influence the parents' assessment.
However, we were not able to determine whether Sox2 might actually behave differently in distinct sub-nuclear compartments and how enhancer clustering might influence the TF search process.
CA2 PN apical dendrites have a number of distinct morphological features compared with CA1 dendrites that might influence spike propagation (e.g. Figures 8A and Figure 10, Figure 10 figure supplements 1 and 2).
We thus cannot exclude that the viruses detected in the meningitis cases may have acquired distinct features in their capsid protein or elsewhere that might influence pathogenicity.
Although self-estimated work-capacity might influence actual capacity, self-estimated effects and actual effects on return to work are distinct entities.
Indeed, some groups have reported that lipid-associated gene expression depends on distinct minor allelic frequency in the human liver, strongly suggesting that lipid-associated SNPs might influence gene expression as the cis-acting regulator at the noncoding region [ 17].
This might influence your long-term success.
