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Nevertheless, after fluid administration, like for any treatment which has inconsistent effectiveness and which might induce significant side effects, it is essential to ask: was volume expansion effective?

We considered, therefore, that minimum doses of long-term exposure STM might induce significant MDR and STM resistance simultaneously, and the resistance could be able to persist even under higher doses of STM among the wastewater bacterial community.

Therefore, the increased intracellular levels of PI 3,5 P2 that result from either MIP ablation or from the natural decrease in MIP function with aging might induce significant imbalances in signaling pathways.

Trials investigating larger doses of hatha yoga in the workplace (e.g. greater frequency, intensity and duration of training) might induce significant adaptations of muscular fitness and physiology, changes that would be highly beneficial to individuals employed in sedentary occupations.

On the whole, the possible association of dyslipidemias with VD or AD is still a controversial issue, probably due to: 1) the very small number of patients included in most of the studies, and 2) the exclusion from the analysis of some important factors that might induce significant modifications in lipoprotein profile.

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With an opinion that a miRNA with too scattering gene regulation might not likely induce significant phenotype, the ClusterOne Cytoscape plug-in [20] was used to disclose the enriched functional module that was comprised of proteins encoded by target genes of the 10 PRmiRs which enhanced regulation was found on the cardiac-specific PPI network (Figure 3).

This important stress might induce a significant increase in myocardial catecholamine levels as suggested by Zouhal et al. [ 35].

The results of several clinical trials demonstrated that mTOR inhibition might induce a significant stabilization of progressive neoplastic diseases and even tumour regressions in a subset of patients [ 64– 64].

Second, the limited increase in adenosine in our model might not be sufficient to induce significant anti-inflammatory effects.

It could be possible that the relative short duration of lemur torpor (compared to other hibernators) might not be sufficient to induce significant changes in expression of genes examined in this study.

This stimulation rate does not induce significant reorganization/plasticity processes that might possibly either affect EEG responses to TMS or interfere with the longitudinal measurements (Casarotto et al. 2010).

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