The maintenance of mitochondrial function in G3mTerc -/-, Sod2 +/- mice suggests that telomere dysfunction might induce adaptive responses that protect mitochondria from oxidative damage possibly involving activation of repair responses.
Together, these findings demonstrate that the combination of sunitinib and RTx might induce clinical responses in different tumor types.
Due to concerns that DNA vaccines might induce autoimmune responses, we measured anti-double stranded DNA antibodies at 0, 4, 8, 12, 24 and 52 weeks and found no abnormalities (Fig. 3A).
O3 is a convenient system to experimentally address the effects of apoplastic ROS since the plant is not exposed to other effector proteins or toxins which might induce defence responses.
However, owing to the lack of physiologically relevant differentiation protocols and chemically defined conditions, it is possible that factors involved in the in vitro differentiation process itself might induce immune responses in syngeneic recipients [ 109, 110].
Activation of TLR2 might induce Th2 immune response, TLR4 induced Th1 and Th17 immune response, and TLR9 induced Th1 immune response [ 14– 214.
Alternatively, embedded ribonucleotides might induce DNA-damage response signaling that itself stimulates interferon production (Brzostek-Racine et al., 2011).
Therefore, the sampling process might induce a stress response independent of whatever previous perturbation is under investigation.
In addition, endothelial cell injury might induce a procoagulative response, leading to microthrombosis and contributing to vascular obstruction and hypoperfusion of multiple tissues [ 20].
Although human MUC1 is homologous to murine MUC1, it is still a foreign protein and might induce an immune response from the host itself.
