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Lastly, greater arousal towards the social interaction condition, which presents with more interesting, salient and therefore endogeneously attracting features, might induce increased activity in regions involved in sustained attention expressed by increased saccades, such as the Frontal Eye Field (FEF) [42].
The mechanism by which removal of K+ might induce increased Na+ influx was not investigated here.
These individuals also have less healthy and more sedentary lifestyles, which might induce increased cardiovascular morbidity (Arango et al., 2011).
Thus, increased collagen synthesis or increased cross-linked collagen content of fibroblasts might induce increased elastic modulus due to nicotine administration in the tendon.
Intestinal macrophages from IBD patients have lost the ability to maintain tolerance, mainly through increased surface CD14 content [ 91] and NF- κB transcription pathway activity [ 87, 92], which might induce increased peripheral macrophage recruitment.
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Furthermore, mechanical ventilation itself stimulates inflammation [ 25] and might therefore induce increased levels of sTREM-1.
If the clinical relevance of our findings is confirmed, then one might think that targeting RhoA could induce increased adhesion and potential homing; down-regulating the Rac1 signaling would induce increase migratory proprieties.
Finally, and in line with the previous suggestion, replication stalling might induce an increased rate of mitochondrial (DNA) turnover, for example, via mitophagy (see also 26), combined with an increased rate of replication in order to maintain normal mtDNA steady-state levels.
Any course that might induce abnormally increased levels of bilirubin accumulating in human serum or plasma usually signifies the presence of a variety of diseases with liver dysfunctions, ranging from jaundice to infectious hepatitis [ 37].
These findings led us to hypothesize that the increased DMT1−IRE expression might induce an increase in DMT1−IRE-mediated ferrous iron uptake by neurons.
Other mechanisms by which indomethacin might induce apoptosis are increased glutathione extrusion mediated by MRP1 (Trompier et al, 2004) or increased ATP consumption by MRP1 ATPase activity in analogy to the observed verapamil-induced ATP consumption in P-glycoprotein-overexpressing cells (Broxterman et al, 1989).
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