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These peptides are of particular interest because their oxidation may not just serve as an early warning of age-induced changes in the oxidative status of cells, but might induce changes in their activity, which are involved in controlling or triggering the oxidation of proteins in general.
When Mukherjee talks about knowing the "causes" of cancer, he means genes and cellular mechanisms gone wrong, not the environmental agents that might induce changes in those genes.
These studies suggest that changes in DA neurotransmission might induce changes in cAMP levels and PDE10A expression.
Acute L-dopa treatment might induce changes in synaptic plasticity, requiring synaptic protein synthesis [19], [20] and degradation [20].
As phosphorylation and dephosphorylation require different conformations [14] and implicitly different interfaces, we examined whether the presence of unphosphorylated form of ERK2 in the complex might induce changes at the interaction interface.
This experiment was completed in a different group of subjects than experiment 1 since rTMS might induce changes in fMRI BOLD activity and could thus have affected the brain imaging results.
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Since changes in DA neurotransmission directly influence cAMP levels in striatum, it is plausible that changes in DA neurotransmission might also induce changes in PDE10A activity.
Since the expression of PDE10A is also most pronounced in these neurons (Lakics et al. 2010; Seeger et al. 2003), it is likely that the alterations in cAMP might also induce changes in PDE10A activity and/or expression as an effective compensating mechanism to normalize cAMP levels.
Therefore, size-selective fisheries might also induce changes in physiological traits (e.g. metabolism) or behavior (e.g. aggression, boldness) that contribute to energy acquisition and hence growth (Enberg et al. 2012; Sutter et al. 2012; Alós et al. 2015).
Therefore, in addition to influencing muscle contraction, the age-related damage and disorganization of sarcomeres could trigger changes in the localization and activity of sarcomere-associated signaling factors, which might in turn induce changes in other cellular compartments.
(I) Mutations in chromatin related enzymes such as DNMTs, histone modifiers or chromatin remodelers might induce stochastic changes in the epigenome causing global changes in chromatin.
More suggestions(15)
might produce changes
might induce modifications
might induce modification
might induce altered
might show changes
might effect changes
might require changes
might induce allergies
might undo changes
might need changes
might avoid changes
might make changes
might involve changes
might include changes
might bring changes
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com