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FHIT protein deletion or reduction might indicate malignant transformation.
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This finding might indicate that malignant cell infiltration into the lymph vessels leads to a shift in sinusoidal macrophage polarization towards the tumor-promoting M2 type.
In the present study, the amount of CD8+ cells in SCC was lower than CD8+ cells in the moderate and severe dysplastic lesions, which might indicate that the malignant lesion is less attractive for CD8+ cells or that the cytotoxic response was reduced in the malignant state.
Furthermore, the lack of malignant neoplasms of above 5-year-old dab might indicate that dab either develop malignant neoplasms and are likely to disappear, or develop benign neoplasms and individuals survive to join the >5 year classes.
Importantly, for MCT2 and MCT4 the expression levels in PIN lesions were between normal and tumour tissue, which might indicate a role for these MCTs in the malignant transformation.
Based on the above observations, we reasoned that expression of CD10 by malignant B cells from ALL might indicate a special cycling ability as well as a propensity to undergo apoptosis.
The low Ki-67 levels in LMP tumours might indicate that most cells are still able to exit from the cell cycle into G0, as opposed to malignant tumours.
This might indicate that the breath-prints of the benign tumours were indeed closer to the healthy states than the malignant tumours, in agreement with the GC MS results.
"His mellow reaction might indicate sympathy".
His record as governor might indicate otherwise.
This might indicate introgression.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com