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In young mice, we only observed a mild increase in red cell distribution width (RDW), also called anisocytosis, which might indicate alterations in RBC production or turnover (Table 1).
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This result is consistent with the absence of GP activity in P1 muscle, and might indicate an alteration in the translation of mutant mRNA or changes in the stability of the mutant protein.
This might indicate that alteration of histone methylation states plays a role in ionic stress.
The results compared with the initial values indicate alterations.
This could indicate alterations in bone turnover.
Lack of the changes in neurometabolites in the thalamus might indicate that the alterations observed in other areas of interest are not related to a different amount of glucose infused.
Subchondral bone-density alterations might indicate osteoarthritic progression.
The study of antibiotic resistance in indigenous water organisms is important, as it might indicate the extent of alteration of water ecosystems by human action.
Our finding might indicate that an early modification induced by exposure of beta cells to elevated concentrations of glucose is the alteration of the phosphorylation status of FOXO1 protein which finally results in a 'de-differentiation' of the beta cells.
However, the persistent alterations in receptor composition might indicate that homopolymeric ProSAP2/Shank3 scaffolds have a higher capacity to cluster glutamate receptors compared to homopolymeric ProSAP1/Shank2 scaffolds.
Apart from the severe developmental disturbance, the observed alterations in mitochondrial organization are interesting and might indicate a functional defect.
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