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The glyoxylate bypass might increase levels of succinate for energy production, surpassing the metabolic branching of TCA intermediaries (e.g., 2-oxoglutarate) for amino acid biosynthesis.

Also, glyoxylate shunt might increase levels of malate, which is further converted to oxaloacetate, a key branching step in the central metabolism.

Alternatively, mutation of mdl-1 might increase levels of free iron in the intestine, perhaps accelerating aging by increasing oxidative damage, as suggested by the free radical theory.

Specifically, in patients with chronic obstructive pulmonary disease it might increase levels of motivation to quit smoking in early stages of the disease.

43 Moreover, epigenetic mechanisms affecting the central nervous system dopamine signalling could be a mechanism by which exposure to elevated maternal BMI during pregnancy might increase levels of externalising behaviour in children.

While self-efficacy is one of the most widely applied constructs across theories of health behaviour and presenting information that provides help to undertake action to protect health (i.e., coping information) might increase levels of self-efficacy [ 52], coping information is only rarely presented in health messages in the public domain [ 53].

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Although it is unclear why aging might increase iNOS levels, other reports have suggested that increased extracellular glucose levels can induce iNOS expression [19], [20].

However, this limitation is unlikely to have influenced the positive association between high NFL levels and a positive AD biomarker profile, as neuroinflammation might increase NFL levels but not the prevalence of a positive AD biomarker status [ 35, 36].

An increase in the perceived safety of parks might increase activity levels, especially among children.

These findings suggest that alcohol might increase GSH levels indirectly as a compensatory mechanism designed to protect the brain from oxidative-stress-mediated insult.

When assessing the effect of deliberate ventilation on occupant health one should consider not only the positive effects on removing pollutants of indoor origin but also the possibility that enhanced ventilation might increase indoor levels of pollutants originating outdoors.

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