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Dietary lactose restriction might improve tolerability of treatment [5].
Except in cases of true allergy, further dose reductions might improve tolerability and still offer a therapeutic benefit.
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Therefore strategies to improve tolerability might be directed in two ways: at those specific physiological abnormalities that identify individuals who are less able to tolerate aspirin irrespective of their age, and at age-related changes in gastrointestinal physiology that might predict why older people tolerate aspirin less well compared with younger age groups (Table 2).
Even though many patients self-administer the subcutaneous IFN injections (in combination with BEV), which might be a potential compliance issue, downdosing of IFN has been shown to improve tolerability and maintain efficacy.
Low-volume bowel preparations for colonoscopy improve tolerability.
Cisapride did not improve tolerability or the frequency of adverse symptoms associated with either solution.
These observations led to an amended study protocol designed to improve tolerability of pemetrexed with folic acid supplementation.
CHCs are available in several regimens and routes of administration (oral, transdermal vaginal) in the attempt to improve tolerability, adherence and convenience of use [11].
However, lower titration schedules may improve tolerability.
In response to these concerns, a 0.01% formulation of bimatoprost was developed to improve tolerability.
Pulse-width was not reduced, although this strategy is commonly used to improve tolerability.
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