Sentence examples for might have off from inspiring English sources

For example, genetic data (deletion or RNAi-mediated silencing) may result in changes in phosphorylation of the target protein but the effects might be indirect; pharmacologic inhibitors might have off target effects and suffer from low specificity; in vitro assays might reveal that a certain phosphatase can dephosphorylate a target but they may never co-localize in the cell.

Nevertheless, the relative genetic lack of amelioration does raise the possibility that HDAC inhibitors might have off-target beneficial effects as well.

Although MO technology is helpful, MOs might have off-target effects, such as non-phenotypes that include activation of p53, which can be suppressed with p53 MO (Robu et al., 2007).

Since our shRNA library covers barely one third of all human genes and some of the shRNAs might not be effective or might have off-target effects, a pathway analysis based on the complete gene interaction network can gain us a more global picture of the inter-relationship of the selected genes.

This may, however, become a more complex issue than just treating with currently available COX-2 inhibitors as these might have off-target effects on immune cells and the microenvironment that could counterbalance their activity as enhancers of susceptibility to immune elimination.

Many were older rams which might have had off-flavors in the fall of the year.

Things might have been off, but they've been off much worse than that before".

The roof might have lifted off to the heavens.

The color might have turned off some potential buyers.

They might have made off with a carpet.

But I think the gamble might have paid off.