Based on the subtle phenotypes and overall viability and fertility of uev-1 mutants, we reasoned that UEV-1 might have a smaller, more selective set of targets for K63-linked ubiquitination than would UBC-13, and that other proteins might function with UBC-13 to conduct most K63-linked ubiquitination events in nematodes.
Though Co-expression of Ki67 with NET-1 in tumors was performed to evaluate cancer cell proliferation, the results showed that NET-1 might function with Ki67 to increase tumor cell proliferation.
Alternatively, PMK-3 might function redundantly with other pathways; indeed, there are two other p38 MAPK paralogs in the genome [53].
We examined whether MLT-7 might function redundantly with the SKPO proteins in affecting the survival of animals in excess iodide (Supporting Information, Table S1).
Plant-based formulations would also increase the number of compounds that are used to limit infections [ 2] and might function synergistically with current therapies [ 3].
The mutant VEGFR (kdrl) analysis is more convincing, but again, are there other genes or isoforms that might function redundantly with the kdrl receptor?
These annotations were mainly consistent with OsSTA genes, except for signal transduction and enzyme regulator activity, which revealed that the genes highly expressed in mature anther might function together with OsSTA genes.
Because C. glabrata calcineurin mutants exhibit similar stress responses to those of C. neoformans UPR pathway mutants, it is possible that calcineurin might function together with the UPR pathway to orchestrate multiple phenotypes in C. glabrata.
Although Nox1 expression in fish or the other non-mammal organisms is not clear, our analysis suggest that Nox1 of fish and birds might function, along with the p40 phox orthologs, in endocytosis, e.g., in receptor-internalization.
Since NOCA-1 has homology to ninein, which has been proposed to anchor microtubules at centrosomes (Mogensen et al., 2000; Delgehyr et al., 2005), we considered whether it might function redundantly with Patronin, another microtubule minus end-associated protein.
SAP126 had previously been shown to be located in a high-molecular weight complex that links one type of scale (i.e., pentagonal scales) to the flagellar membrane (Becker et al. 1996), and in this study, SAP98 was also localized to flagella, suggesting that SAP98 might function together with SAP116 as a second scale receptor, presumably for hair scales (fig. 4 B).
