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In principle, inappropriate clinical performance might flaw the outcome of a clinical trial to the same extent as methodological biases.
It is, however, not only the variety of indices, but also the lack of knowledge about their validity, which might flaw current approaches.
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The time-limited follow up in randomized controlled trials might also flaw the understanding of a treatment's effect, since it does not apply to a patient's lifetime perspective.
Traits that others might consider flaws, such as her reputation for pragmatism, they applaud.
The tribunal process might have flaws, but these imperfections are worth having if justice is served in the end.
But once they reach a sufficient scale without a big blow-up, nobody believes that they might be flawed.
Ivan Oelrich, the director of the Federation of American Scientists' strategic security project, said he worried that the whole "cooperative" approach might be flawed.
" . . . and if anyone here suspects that the algorithm that put these two together might be flawed, speak now . .
The company said the trial might be flawed because it used shocks from the devices as the measure of which patients suffered life-threatening heart irregularities.
Some Democrats privately expressed concerns that the methodology used by Standard and Poor's might be flawed, underestimating the true costs of educating children in impoverished areas.
They suggested that some of the theoretical models of conditions toward the edge of the solar system, far from the nine planets, might be flawed or oversimplified.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com