TGF-β signaling may not be the same in different tissues, which might explain the tissue-related manner of the association between TGFBR1*6A genotypes and cancer development.
Nevertheless, mitochondrial dysfunction, as it may occur during sepsis, might explain why tissue hypoxia persists in spite of increased oxygen availability [6] (Fig. 1).
Similar observations were made previously for some tumor cell lines in which telomerase activity is limited by levels of TR (Cristofari and Lingner, 2006; Xu and Blackburn, 2007), and might explain the tissue-specific impact of TERT and TR mutations in patients with dyskeratosis congenita (Batista et al., 2011; Strong et al., 2011; Armanios and Blackburn, 2012).
Detailed biochemical studies in different human tissues, especially in the genitourinary vs UADT region, might explain the opposing tissue-specific effects of SULT1A1.
This theory might explain that endometrial tissues can be iatrogenically transported into the abdominal wall or into the scars of the surgery.
This continuous need for import and export of metabolites in heterotrophic tissue might explain the high stromule abundance in BY2 cells as well as in non-green tissue like ripening tomato fruits and dark grown seedlings.
50 This might explain the increased adipose tissue deposition in older subjects.
The migration of lymphocytes from the circulation to tissue might explain this rapid drop in lymphocyte count and the resulting immunopathological damage [ 27].
The fact that the invadopodia can use physical force to burrow through tissues might explain why drugs that work to inhibit the activity of proteases haven't been particularly effective at preventing metastases, the researchers said.
Accordingly, exposure to cytokines secreted in vivo in the microenvironment of lymphoid tissues might explain why resident naïve CD4+ T cells are permissive to the virus [1] [5].
