This might explain why a DON deficient mutant colonises maize cobs similar to wild type, although the wild type produced high levels of DON during the infection [ 13].
The conclusion that in strain 21B4 a constant increased O2 production is responsible for high GPXH expression might explain why no GPXH induction deficient mutants could be isolated, because GPXH might be essential for defense against O2-induced damage.
Abnormality of DC development observed in ATM-deficient mice might explain the defect and malfunction of immune system of ATM patients and their multiple disease status.
A functional redundancy of the different ATG4 proteins in mammals might explain the notion that ATG4C deficiency does not alter basal autophagic activity in vivo and the fact that ATG4C-deficient mice survive the neonatal starvation period (Ref. 38).
Consistently, a previous study suggested that a decrease in cell size might explain the smaller brain of N-myc-deficient mice (Knoepfler et al., 2002).
Examination of additional molecular parameters that might explain this delay in apoptosis induction in Stat3-deficient mammary epithelium turned up two interesting differences between that Stat3 expressing and nonexpressing glands.
This might explain partly why adipocytes of C/EBP- β and C/EBP- δ deficient mouse embryonic fibroblasts (MEFs) have reduced GLUT-4 mRNA expression [ 97].
Therefore, this might explain why a GPP-knockout mutant of Arabidopsis is only partially deficient in AsA content [7].
The role of monoubiquitination in promoting the nuclear localization of PTEN might explain the cytoplasmic localization of the double SUMOylation and monoubiquitination-deficient PTEN proteins.
Hence, loss of suppression of EGFR signaling by lack of E-cadherin/catenin EGFR intE-cadherin/catenin EGFRes winteractionrmline mutations migHDGCxplain the increased sensitivity to EGfamiliesI3K kinase inhibition in CDH1-deficient HDGC (Fig. 1).
