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Since DOCK8 is involved in several cellular processes in the immune system18,20,30,33, this significant decrease in lymphocytes of autoimmune cases might explain changes in the immune response in disease.
Since DOCK8 is associated with important immune functions, our finding of significantly decreased DOCK8 expression and altered DOCK8 interaction network in ERU might explain changes in immune response and shows the contribution of DOCK8 in pathomechanisms of spontaneous autoimmune diseases.
In general, while unbiased transmission (i.e. random copying) might explain changes in the distribution of certain cultural traits [30], cumulative cultural evolution requires direct or indirect bias.
However, our data are too limited to give a precise description of the inflammatory processes that might explain changes in central fatigue.
In addition, differences in epigenetic modifications might explain changes in disease susceptibility in the absence of DNA sequence variation.
Furthermore Douglas et al. (2011) hypothesize that weather conditions and resulting prey availability might explain changes in breeding abundances that do not immediately result from wind turbines.
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During her Fellowship at the Carr Center, she is working on primary sources from the Inter-American Human Rights Systevidenceining evidence on how individual roles might explain change, continuity and effectiveness of this regional human rights system.
The colour change that we found in G. sibiricus is much slower, but since granule migration might simultaneously explain changes in darkness in both directions, it might contribute to our observations.
5 6 We did not address secular trends in screening and risk factors for disease, which might also explain changes in incidence.
It is possible that these changes might in part explain changes in appetite and sleep occurring during the state of depression.
These models allow us to test the hypothesis that cladogenesis in parmelioid lichens is associated with shifts in habitat that might in turn explain changes in nucleotide substitution rate.
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