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Since previous tract tracing studies have focused on the visual cortex, there might exist additional connections mainly within and between motor, auditory, and somatosensory cortices.
On the other hand, one possible explanation might be that apart from the suggested role in mitosis, there might exist additional functions of PLK isoforms in intracellular signal transduction pathways.
Recent reports, however, have shown that ERBB2-positive CTCs can be detected also in patients with ERBB2-negative primary tumors (Riethdorf et al, 2010; Ignatiadis et al, 2011; Hartkopf et al, 2012), suggesting that there might exist additional patients that could benefit from ERBB2-directed therapies.
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The model suggests that compounds with appropriate substitutions at C4 or C5 of the benzene ring might exist that provide additional interactions with D339 and thus increase the affinity of the compound to PHD HD1.
Thus, we cannot exclude that additional regulatory mechanisms might exist, but we would need additional, independent data to confirm or refute such a hypothesis.
Southern blotting, which utilized much longer probes than the PCR primers, indicated that additional genes might exist in the RH1, SWS1 and LWS opsin gene subfamilies.
The recent report showed that STIM1 can inhibit L-type voltage-gated Ca2+ channels in neurons [24], indicating that the mechanisms of calcium homeostasis in neurons are more complex than anticipated, and additional links might exist between voltage-dependent Ca2+ channels and SOCE.
Besides this main barrier, additional channels might exist within the rigid framework of NPCs.
Because these factors are important contributors to CRC growth, we sought to determine whether additional relationships might exist between gastrin and β-catenin.
Interestingly, the site does not seem to provide the full binding capacity of the receptor but an additional site might exist (Albritton et al, 1993; Qian et al, 2003).
The fiber topography in posterior fusiform gyrus indicated that additional retinotopic areas might exist, located between the recently identified retinotopic representations phPITv/phPITd and PHC-1/PHC-2 in lateral occipital cortex and parahippocampal gyrus.
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