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Our studies significantly advance the understanding that Tau aggregation might exert protective cellular effects, at least briefly, when neurons are facing neurodegeneration stimulus.
This phenomenon reconfirmed the HO-1 induction property of VitC and suggested post-treatment with VitC might exert protective effect via enhancement of HO-1 after HS.
For example, it may be that only particular antioxidants (possibly in combination with others) might exert protective effects on clinical or biological conditions, or that only specific populations might benefit from an antioxidant supplementation (ie, only subjects with low antioxidant and/or high oxidative stress levels).
Observational studies have also reported inverse associations of cardiovascular disease with dietary intake or plasma concentrations of omega 3 fatty acids (mainly eicosapentanoic acid and docosahexaenoic acid), suggesting that supplementation with omega 3 fatty acids might exert protective effects on cardiovascular disease.
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Compatible with the findings from the ALLEGRO trial, experimental data suggest that LAQ might also exert protective central effects in EAE [ 46].
Our data suggest that adiponectin might be able to exert protective effects on mammary epithelial cells only, whereas MCF-7 breast cancer cells might have lost the ability to respond to this adipocytokine in a similar manner.
The present results indicate that dietary restriction might exert a protective effect against chronic-ethanol-induced changes in exploratory behavior.
However, a previous study in IBD patients suggested that heterozygous carriers of the ΔF508 mutation in the CFTR gene, the main susceptibility gene for patients with cystic fibrosis, might exert a protective effect in CD [49], suggesting opposing effects of genetic risk loci for cystic fibrosis and IBD.
Regular vitamin C supplementation might exert a protective effect on the development of gallstones.
This finding suggested that abatacept might exert its protective effect on podocytes by blocking this disruption.
The Achyranthes bidentata polypeptides might exert their protective effects against neuronal apoptosis through modulation of the PI3K/ AKT/GSK-3β pathway [ 47].
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