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As a consequence, locally increased oestrogen levels might exert activating effects on synovial cell proliferation, including macrophages and fibroblasts [ 38].
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These results clearly demonstrate that dh404 activates Nrf2 in the heart, suggesting that dh404 might exert cardioprotective effects via activating Nrf2 signaling.
Mechanistically, p66 might exert this effect by activating p44/p53 signalling after oxidative stress.
It has also been suggested that the Phd antitoxin might exert its action by activating another protein that neutralizes the Doc toxin [ 7].
Flavonoids Naringenin and hesperetin might exert anti-atherogenic effects partly through activating peroxisome proliferator-activated receptor and up-regulating adiponectin expression in adipocytes [100].
These results suggested that RG27 might exert its cytotoxic activity by disrupting RasGAP-Aurora B interactions.
Since these genes were not affected in the ams mutant, some lipid metabolic genes might be activated independent of AMS and they might exert functions earlier than AMS or in parallel to AMS [ 63, 64].
The recently deceased might exert influence on the living for good or for bad.
In the highest dose MPEP might exert anxiolytic properties.
Alternatively, VNS might exert migraine prophylactic actions by modifying cortical excitability.
This class of drugs might exert its inhibitory effects at both cortical neuronal and cerebrovascular levels.
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