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S1/Dox treated cells, however, mostly accumulated the nanoparticles in cytoplasm, which indicates that nanoparticles might enter cells via an endocytosis pathway.
The observation that cisplatin activated caspase-3 in WT cells more efficiently when applied in hypotonic medium suggested that cisplatin might enter cells through VRACs.
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Studies have suggested that exogenous LPA might also enter cells to activate PPARγ because LPA can bind to and displace rosiglitazone from PPARγ.
Bacterial membrane damage raised the possibility that 17BIPHE2 might also enter cells and bind DNA.
The MCT is implicated as a 3-BP transporter and free 3-BP might not enter cells in the absence of MCT.
However, these data do not exclude the possibility that CT might also enter cells via additional mechanisms, a point that we attempted to make more clearly in the revised manuscript.
Because cathepsin B is activated by low pH in acidic endosomes, the CD4-independent mNDK vector might enter host cells through acidic endosomes.
This was performed with the idea that even though proteins at intermediate concentrations of chitosan did not leak out, small molecules such as NADP+ and glucose-6-phosphate might enter the cells and reach the enzyme inside, allowing to find out about its integrity.
It might enter the cell and (like other viruses) subvert some of the cell's machinery to its own ends and multiply until the cell burst, releasing viral progeny to infect other cells: or it might not replicate at all but nevertheless induce cancerous transformation.
Moreover, our results also suggest that the human Oct4 protein might be able to actively enter cells via the Oct4-PTD, further supporting the concept of 'signalling homeo-proteins' found in mammalian but also plant cells [ 66, 67].
They speculated that part of the negatively charged GNPs might adsorb serum protein and enter cells via the more complicated endocytotic pathway, resulting in higher cytotoxicity and immunological response [ 40].
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