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Thus, at the onset of the disease, those patients cannot generate immunoregulatory Th2 cells that might downregulate ongoing Th1-mediated inflammation.
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Therefore, we asked whether ACL KD might downregulate cancer stemness.
This indicated that nematodes might downregulate the expression of RAP2.6 to avoid resistance responses of the plant.
First, we hypothesized that aging might downregulate the levels of the peptide receptors on ASEL neurons, thus reducing signaling in aged ASEL neurons.
The downregulation of epidermal growth factor receptor activity by SHP2 might downregulate ERK1/2 signaling (Additional file 5: Figure S4).
Also associated with the first gene is the set of the genes which byproducts of its transcription might downregulate, identified relative to searches involving sequence alignments.
However, these genes did not pheno-copy Fir1 upon RNAi, suggesting that Fir1 might downregulate other new genes to drive local proliferation (Figs. 1B D and S1B, data not shown).
MTX might downregulate serum TNF α in RA [ 25].
Firstly, the high concentration of 5-FU might downregulate TP expression.
34, 35 Therefore, TGFβ might downregulate miR-639 via suppressing E2F1 expression.
Alternatively, the tumour might downregulate or modulate the expression of antigens, thus evading immune-cell detection.
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