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Possibly also other tissues, such as the liver, might display increased macrophage infiltration and M2 polarization during critical illness, for which further study is needed.
Neuronal and glial populations with higher secretory requirements might display increased sensitivity to genetic and environmental factors that disrupt ER function.
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As neoplasms display increased 18F-FDG uptake, this might lead to false positive readings.
A plausible extension of this hypothesis is that clinically aggressive drug-resistant SCLC cells that emerge after chemotherapy might have a more extensive network of neuropeptide regulation and therefore display increased sensitivity to neuropeptide antagonists.
By contrast, the third instability subgroup, GII-high-III, was found to display increased propensity to acquire small copy number gains which might relate to the previously proposed 'amplifier phenotypes' and possibly 'complex-firestorm patterns' in breast tumours [ 27, 31].
Patients with diabetes are known to display increased populations of circulating platelets that express activation-dependent adhesion molecules that may contribute to increased aggregation and might provide new pharmacological targets [ 32].
Distressed rodents display increased avoidance of the open arms.
PRDM16 transgenic mice display increased energy expenditure.
Some other cancer variants also display increased PTPRZ expression [ 38].
We also observed that the treatment with infliximab in cells incubated with serum from normotensive subjects displayed increased eNOS expression, suggesting that TNF- α might impair NO synthesis in ECs.
Genes with higher levels of PolII displayed increased nucleosome turnover surrounding the TSS, as might have been expected from the positive correlation between steady-state RNA levels and nucleosome turnover (Deal et al., 2010; Yang et al., 2013).
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