There was also evidence for the involvement of more than one residue from our stopped-flow FTIR data that estimated the movement of approximately seven peptide bonds alongside the pre-steady-state chemistry.[ 9a] Such a movement might not directly involve seven side chains, but does suggest a flexible, dynamic active site in EAL.
In this model, UNG2 and CENP-A might co-exist transiently in repair foci, and UNG2 might be directly involved in CENP-A recruitment to damaged DNA or repair complexes.
EGFR also identified in some parasites, and it was believed that EGF signaling could be conserved in helminths and might be directly involved in host-parasite molecular interplay (Dissous, Khayath, Vicogne, & Capron, 2006; Vicogne et al., 2004).
These data suggested that IMPDH2 might be directly involved in the development of chemoresistance.
We examined whether FUS-DDIT3 might be directly involved in the control of the eIF4E expression.
Together these experiments indicate that PIASγ might be directly involved in the removal of cohesion.
Because the results so far suggest that FUS-DDIT3directly regulates PPARγ2 expression, we examined whether FUS-DDIT3 might be directly involved in the control of PPARγ2 transcription.
One can hypothesize that some genes in the sae regulon might be directly involved in the protein translation process and can affect ribosomal sensitivity to the antibiotics.
Collectively these latter findings lead to the hypothesis that nucleocytoplasmic shuttling of proteins deriving from synapses and dendrites might be directly involved in plasticity-related gene expression and thereby contribute to memory formation [3], [10].
In order to examine whether FUS-DDIT3 might be directly involved in the control of C/EBPα transcription, we carried out reporter gene assays using a luciferase reporter gene containing 1171 bp of the promoter region of the rat C/EBPα gene (pCEBP1171) [36].
