The Crumbs and Bazooka complexes play critical roles in directing rhabdomere development [4 9], but whether they might direct cell-type-specific apical architectures is unknown.
Although several broadly acting transcription factors have been shown to control synapse number, the identity of the transcription factors that might direct cell-type specific features of synaptic development remains elusive.
Indeed, in cultured hepatocytes, TGF- β is capable of rapidly activating AKT which thus might direct the cells towards EMT.
In this respect, some chemical mediators or ligand-receptor interactions (i.e. VEGF ligands and VEGF receptors) might direct the neoplastic cells to the lymphatic vessels.
The observation that abdA is regulated as a consequence of dsx, suggests that during pupal stages, dsx might direct aspects of cell-fate identity, rather than acting in a parallel pathway to overlay sex-specific regulation information onto cells that are directed to their cell-fate identities in a non-sex-specific manner.
Moreover, IFIT4-primed DCLCs stimulated greater IFN-γ secretion by T cells, which suggests that IFIT4 might direct DCs to modulate Th1 cell differentiation and favour the ability of DCs to skew the immune response toward Th1 development.
It might be during the fate specification of ball-producing versus socket-producing cells, and/or during their differentiation and maintenance, in which Notch might direct the expression of specialized cuticular components and regulators of cell movement, etc.
Furthermore, the DNA replication process itself might direct the different chromosome arms into the designated cell half.
G9a might direct DNA methylation at such hypomethylated sites through recruitment of de novo DNMT3A/3B enzymes, similar to its role in ES cells [ 23].
This might be useful for examining directed cell interactions, or to enhance the biocompatibility of inorganic materials used as substrates in tissue engineering or devices that are to be implanted into the body.
