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The possible presence of M3R in the vasculature, reduced blood flow responses and salivary secretion to muscarinic receptor activation support the notion that M3R autoantibodies present in NOD mice might critically impair fluid transport required for salivation.
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The effects of fragmentation have been shown to critically impair the ability of an ecosystem to provide viable habitat through decreased area, increased isolation and edges [39].
Pancreatic ductal adenocarcinoma (PDA) is characterised by stromal desmoplasia and vascular dysfunction, which critically impair drug delivery.
A systemic-risk regulator could also assume the important function, currently lacking, of a sort of F.D.I.C. for nonbank financial firms, with authority to seize and restructure critically impaired firms before they threaten the broader system.
However, its physicochemical instability critically impairs its dosage form design, evaluation and administration.
Similarly, experimental animal models attempting to demonstrate impaired cellular oxidative bioenergetics or abnormal lactate/pyruvate ratios have not demonstrated evidence of critically impaired oxidative metabolism during sepsis [44 47].
In this concept, patients with a critically impaired pulmonary gas exchange remain candidates for ECMO.
It seems that the protein synthesis machinery is critically impaired by staurosporine.
This method might critically help improve the interpretation of such experiments.
Also, studies have shown high levels of anxiety and psychological distress in family members of critically ill patients, which might impair their ability to give adequate informed consent for research participation for incapacitated patients [51, 52].
Also, studies have shown high levels of anxiety and psychological distress in family members of critically ill patients, which might impair their ability to give adequate informed consent for research participation for incapacitated patients [ 51, 52].
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