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We hypothesized that Wnt signaling might control nucleus pulposus homeostasis in normal intervertebral discs.
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Because we had demonstrated that survivin-2B was mainly localized in the nucleus, we hypothesized that survivin-2B might control the expression of proteins related to autophagy.
Because of the dual location of Usb1p, in the nucleus and mitochondria, it is tempting to suggest that Usb1p might control the processing or stability of nuclear and mitochondrial RNAs.
On the one hand, skNAC-Smyd1 appears to control transcriptional processes in the nucleus, on the other hand, specifically at later stages of myogenic differentiation, both proteins translocate to the sarcoplasm and at least Smyd1 specifically associates with sarcomeric structures and might control myofibrillogenesis and/or sarcomere architecture.
A possible source for missing neurogenesis might be seasonal variations, as observed, for example, in the song control nuclei of songbirds [23].
For the control cells without treatment, cells nuclei were normal as shown in (Figure 4A, control nuclei).
Nuclei in DNp150-expressing cells "start" from more basal positions and must therefore translocate further than control nuclei.
But during spontaneous precipitation, there are no existing surface sites and Sr partitioning might be mainly controlled by the first nucleus of crystal at critical supersaturation.
Mitochondrial transcription is controlled by nucleus-encoded transcription regulators that localize to either the nucleus or the mitochondrion.
We speculate that blocking this pathway might protect nucleus pulposus cells against degeneration.
We speculated that blocking the Wnt signaling might protect nucleus pulposus cells against degeneration.
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