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We also investigated whether a subset of highly polymorphic (≥ 4 SNPs) genes might contain functional changes.
As plant CNSs contain DNA-binding motifs (Freeling and Subramaniam 2009) as they do in mammals (Pennacchio et al. 2007; von Rohr et al. 2007), motifs known to be short and inexact (7 12 bp with alternatives), some of the At αCNSs should not be detected in Br even though they might contain functional motifs because the motifs are shorter than the minimal length of detectable CNSs.
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The low LOR(s) values of the putative SphR binding sites in the genomes of CCMP1375, CC9311 and CC9902, in which no sphR gene is found, indicate that these genomes might not contain functional SphR binding sites.
The controlled coalescence of droplets might be a promising approach to fabricate such particles since different droplets might be composed of distinct components or might contain diverse functional solutes.
We agree that the well-conserved non-globular segments might contain useful functional annotations like the cases of many diverse PTM sites/motifs.
The construct pRF +4/+258 displayed a high firefly activity in HeLa cells compared with the control empty vector, consistent with the possibility that the region between the two AUGs in the first exon of SPG4 might contain a functional IRES.
A simple hypothesis to explain the increased length of first introns is that these introns contain functional elements that are present in addition to what might be regarded as 'normal' intron structure.
Since their cells did not contain functional p53, Martin et al. considered whether p73 might be playing a role in the regulation of Noxa expression.
Resequencing of the whole candidate region might be too expensive; therefore, it is important to identify regions that are most likely to contain functional polymorphisms.
The titles contain functional annotations.
The sequences are spliced and titles contain functional annotation.
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