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On the other hand, many other reported effects of estrogen in hippocampal area CA1 might confer increased sensitivity to ischemia, either by modulating the excitatory effects of glutamate or by modifying the inhibitory effects of GABA.
Therefore, the major alleles of candidate SNPs within these loci represent crucial alleles for β-cell dysfunction and, thus, might confer increased susceptibility of β-cells towards adverse environmental factors.
In an attempt to discover factors that might confer increased cell survival following transplantation, we initiated a genetic screen for insertional mutations that conferred resistance to oxidative stress in human myoblasts.
Therefore, the major alleles of type 2 diabetes candidate SNPs within these genetic loci represent crucial alleles for β-cell dysfunction and, thus, might confer increased susceptibility of β-cells towards adverse environmental factors.
The molecular mechanisms that might confer increased risk on these complex traits are incompletely understood.
The longer R gene might confer increased specificity for pathogen recognition in the three Chinese wild Vitis species.
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If, however, observed effects are due to an association between smoking during pregnancy and other confounding factors, paternal smoking during pregnancy might also confer increased risk through both genetic and social environmental confounders.
12 Thus, while beneficial in some contexts, the peripheral effects of SSRIs and other serotonergic antidepressants might also be expected to confer increased risk for vascular or bleeding complications.
Particularly, constitutional hemizygosity of 18q has been reported to confer increased risk of autism.
Cumulatively, these relationships confer increased risks for CVD.
Other mutations in BRAF also confer increased kinase activity.
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