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The preservative in question, known as thimerosal, was used in many vaccines to prevent microbial contamination until concerns were raised in 1999 that cumulative doses of mercury might cause subtle harm to the developing brain.
The authors suggest that these genetic variants might cause subtle differences in brain structure related to pitch perception, and that populations that harbored a high frequency of the variants might have been more likely to develop nontonal languages.
Extensive and inappropriate usage of portable music players might cause subtle damages in the auditory system, which are not behaviorally detectable in an early stage of the hearing impairment progress.
The authors concluded that the noncoding variants might cause subtle key differences in transcription or epigenetics that influence autoimmunity.
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These findings indicate that reduced Tfap2a levels do not cause drastic changes in the expression of a specific set of gene targets, but instead might cause more subtle differences in the overall gene regulatory network controlling facial development.
In contrast with these very rare, gene-specific mutations, more common variations in genes (polymorphisms) might cause more subtle variations in DNA repair capacity at the population level, in particular when multiple genes from one pathway are studied [ 109].
Although we cannot rule out that the Dido3ΔCT-RFP allele might cause a subtle neomorphic phenotype, these data support the interpretation that elimination of the C-terminal portion of Dido3 compromises Dido3 function, resulting in early embryonic lethality.
The theory that low environmental levels of a variety of organic chemicals might be causing subtle but widespread developmental and reproductive effects on both humans and animals arose from a Wingspread conference and the book Our Stolen Future (Colborn et al. 1996; see also vom Saal 1995).
Alcohol is a teratogen, a neurotoxin that can cause subtle developmental disabilities to profound brain damage.
Furthermore, despite the use of standardized sample collection, handling and storage protocols, it is difficult to retain identical conditions at and during transport from different clinical sites, where even subtle fluctuations might cause variations in the downstream analysis.
Besides direct effects on mortality, neuroglycopenia might cause neuronal damage and at least subtle permanent neurocognitive impairment that potentially affects life quality after discharge.
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