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Below we discuss the origin of specific defects and factors that might cause phenotypic variability in ribosomopathies.
With the development of space science, it is important to analyze the relationship between the space environment and genome variations that might cause phenotypic changes in microbes.
Human activities are altering ecosystems across the globe, but how strongly, consistently, and predictably the resulting ecological shifts might cause phenotypic shifts in affected organisms remains poorly understood.
Even genes that do not show dosage effects in isolation might cause phenotypic abnormalities if one or more additional pathway members are simultaneously deleted.
SNPs in upstream and downstream regions might cause phenotypic variations because they often activate or suppress gene expression by causing substitutions in regulatory sequences, e.g. promoters and terminators.
One way around these limitations is to examine and analyze gene expression from many individual genotypes that each contains multiple mutations and to study the covariance in phenotypes and multiple gene expression levels to hypothesize which of the gene expression changes might cause phenotypic deviations [ 38- 41].
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Conceptually, a segmental model of the raphe system leads us to expect heterogeneities, since rhombomeres have partially distinct molecular identities that might cause variant phenotypic aspects, as opposed to the common neurotransmitter phenotype, which is probably due to a set of shared genetic determinants.
Antipseudomonal antibiotics use might be associated with increasing MIC values that does not cause phenotypic switch on disk diffusion.
We hypothesized that selection of a particular strain(s) of secondary endosymbiont and genome modifications such as adenine methylation might contribute to the adaptation of the selected aphid variant and cause phenotypic changes.
The present study tests the hypothesis that heterotypic stromal-epithelial interactions cause phenotypic changes in urothelium.
Some of the polymorphisms cause phenotypic variations and diseases.
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