Besides osteoarthritis there are various conditions which might cause increased bone turnover and uptake on bone scan like older trauma, benign bone lesions like enchondroma or osteonecrosis.
However, the significantly higher blood level at 1 h p.i. after PEGylation might cause higher bone marrow toxicity and could therefore be a potential drawback of PEGylation.
"It's important to sort out the factors that might cause poor bone quality," Mooney says.
The moderately long TMP/SMX regimen recommended can cause bone marrow suppression, and it is recommended that patients who might be folate deficient be given folate supplements.
This might cause muscle and bone damage as well as neurological issues.
Large errors in measurements of available bone height might cause nerve injury during the insertion of the implant.
Using those cement spacers, there is concern of violation of the acetabular bone which might cause pain and further erosion during weight-bearing activity.
In arthritis, synovial macrophages might cause joint destruction by differentiating to bone-resorbing osteoclasts [ 20] or by releasing cartilage-degrading enzymes and cytokines, such as interleukin-1 and tumor necrosis factor-α [ 8].
PMMA has Young's Modulus (measure of stiffness) between 1,8 and 3,1 GPa, is more elastic than human bone (14 GPa for cortical bone), and, because of the stress shielding effect PMMA, might cause osteopenia [ 85].
During oral rehabilitation by dental implantation for mandibles reconstructed with plate and screws, intensified stresses can develop at the implant-bone interfaces and fixation screw bone interfaces that might cause complications at these interfaces.
