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However, at higher mRNA concentrations some tRNAs might become limiting, leading to a decreased yield of full-length protein in the non-tRNA-supplemented samples.

Because shortened telomeres mimic DSBs, we speculate that DSB repair proteins, either for HR or NHEJ, might become limiting as well in the presence of shortened telomeres that resemble DSB sites.

This has been suggested for ruminants, due to the high proportion of energetic methane losses in this group [25]; for nonruminant mammals, these losses might become limiting at extrapolated body masses of 100 metric tonnes [26] – a putative constraint that might apply conceptually for the largest dinosaurs [1].

This results in a continuous withdrawal of guanine precursors, such as guanosine and its nucleosides and nucleotides, so that, dGTP, required for mitochondrial DNA replication, might become limiting, therefore requiring active import of either its precursors or dGTP itself.

For example, there is a difference between a LIP/LAP ratio, for example, 8/2 or 100/25, while both ratios seem equal: 4. At high amounts of the transcription factors the biological effects are likely to differ when compared to lower concentrations, for example, at high dose (one of) the heterodimeric partners of LIP/LAP might become limiting or all binding places might become fully occupied.

Similar(54)

Thus, where syntenin may become limiting at some point (and exosome numbers might stagnate), heparanase might still increase the 'lateral association' or clustering of syndecans, further stimulating the incorporation of syndecans and syndecan-associated proteins in exosomes.

It might be speculated that further optimization of such a strain would require an optimization of glucose uptake and glycolytic flux because these processes become limiting.

That was when I decided I might have to look further afield, as my opportunities in this country had become limited.

Another option is that intracellular concentration of itaconate and the lack of transport capacity might become rate limiting, which was also proposed by Okamoto et al. (2014).

In glucagon high states or in T2DM, Gly might become a limiting factor in GSH synthesis [ 32].

As a result, in cells with high levels of protein trafficking, the availability of COPII carriers might become a limiting factor, and other proteins might displace collagen molecules.

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