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Hypothesising that collagen breakdown products produced during tissue digestion simulate the early phase of healing and thus stimulate upregulation of tendon markers, collagen 3 expression might be upregulated rather than collagen 1 expression.
The fact that CHC silencing increased PrPSc uptake prompted us to test if alternative internalization routes might be upregulated by this treatment.
Therefore we tested whether ErbB2 expression might be upregulated in PERKΔC vs. β-Gal cells.
We therefore hypothesized that pros expression might be upregulated in new born neurons of the OPC and CB.
The mechanisms through which levels of mTor might be upregulated and Atg7 downregulated in DLB and α-syn tg mice are not completely clear.
Because TRPM8 and TRPA1 displayed a reduced expression after injury we reasoned that another cold-sensitive ion channel might be upregulated instead.
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It is therefore tempting to speculate that release of RAP1 from telomeres upon TRF2 deletion might be upregulating pronecrosis genes.
Therefore, we speculated that molecular machinery found to promote EMT might also be upregulated in the cycling hypoxia-selected subpopulation.
Autophagy has not been examined in this context but might well be upregulated given its crucial role in senescence (Ref. 91).
We then used qRT-PCR to determine whether the upstream regulators of these hormones might themselves be upregulated in scrapie-infected mice.
The transcriptomic results and qPCR data showed that pi3ks, cbl1, cbl2, and cbl3 are all upregulated by Ras1CA, whereas the qPCR data of pi3kl did not match its transcriptomic result suggesting it might also be upregulated by Ras1CA.
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CEO of Professional Science Editing for Scientists @ prosciediting.com