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If the two data sets were combined, the genome might be sequenced much sooner.
Some patients might be sequenced multiple times as a tumor spreads and mutates.
And third, as current NGS technologies incorporate PCR steps in their library preparations, multiple reads originating from only one template might be sequenced, thereby interfering with variant calling statistics.
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The reason might be sequencing errors and potential sequence variations among individual plants.
In other cases, we have no clear explanation, and might be sequencing errors and/or mutations in cosmid clones used in the original sequencing.
Some of these singletons might be sequencing errors in the pre-/early-vaccination sequences caused by partial degradation as also observed in other ancient DNA studies [ 33].
Therefore, the SQ dipeptide may not be absolutely necessary for DGR activity; however, as in the case of the truncated RTs discussed above, the apparent mutations might be sequencing errors or very recent inactivations.
Interestingly, synergy might be sequence-dependent for oxaliplatin and docetaxel.
How this mechanism might be sequence specific or promoter specific remains to be determined.
As this is not observed for the Tg single-stranded substrate, the possible contaminating activity might be sequence dependent.
The reviewers make the interesting suggestion that there might be sequence replay events during spontaneous period activity.
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CEO of Professional Science Editing for Scientists @ prosciediting.com