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A major reason might be population genetic differences in terms of allele frequencies and in terms of the contribution of individual risk variants.
However, some studies have failed to find any association between mtDNA and longevity (Dato et al., 2004; Pinós et al., 2012; Collerton et al., 2013), suggesting that the possible effect of mtDNA on longevity might be population specific, but also that such an effect might be minimal, and require a very large number of samples to reach statistical significance.
Similar(58)
Alternatively, evidence for selection might be population-specific.
Therefore, the detected variants might be population-specific (30).
The frequency of TLR4 1063A/G alleles and their association with preterm labor might be population-specific.
Another study suggested that the carcinogenicity of EUR-350T vs EUR-350G might be population-dependent also within Europe (Zehbe et al, 2001).
The identification of genetic elements underlying these ethnic-dependent phenotypic variations is a strong suggestion that the mechanisms and propagation of MNDs might be population-specific, meaning that one-size-fits-all drugs and diagnosis platforms would not be effective for all patients.
On the other hand, the association might well be population-specific.
Besides being time-dependent, PASS might also be population-dependent, as different sub-groups had different PASS thresholds.
Another direction of improvement might be considering population models more advanced than the stable population.
So there might be large population groups missing – especially in countries undergoing rapid change.
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