We note a frameshift in exon 2 generating a predicted 35 amino acid protein that might be a null, has been reported in a family with ALS, but data regarding segregation are unclear making conclusions uncertain (Hu et al., 2012).
The second mutation p.K635RfsX10 lacks the C-terminal responsibleonsible for XRCC4 binding and LIG4 stability and activity, and therefore this mutant might be a null mutation as well or have very low residual activity.
Nominations not attaining this threshold shall be null and void".
As might be expected, SphK1 null mice have about 50% of normal S1P blood levels.
However, it is not clear whether the deletion in the intron might be responsible for null gene expression.
If controls with missing vaccine history had lower vaccination rates than cases with missing history, effectiveness estimates might be biased towards null.
Selection pressures to maintain a stable morph frequency across all populations might be the appropriate null expectation of population divergence for polymorphisms that transcend species boundaries, and when alleles are maintained by negative frequency-dependent selection [ 77- 79].
If we collectively do nothing, a phase III study might be rendered scientifically null by a critical mass of participants making intentional protocol violations on PatientsLikeMe, Facebook, or Twitter.
As the retroviral insertion site is located in an intron upstream of the exon containing the ATG start codon of Sulf1 (Fig. 1A), we suspected the allele might be hypomorphic rather than null.
Note that our strategy considered SNPs are independent from each others which might be reasonable under the null hypothesis of neutrality given our marker density and background LD within the different populations (see Results).
Similarly, impairment of NF-κB under positive selection circumstances might be sensed as a null signal, triggering death by neglect [ 22].
