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DIGGIT looks upstream of master regulators to distinguish driving mutations of cancer from other genes that might be mutated, but are not actually involved in causing and maintaining cancerous cell states.
Hudspeth's team plans to look for genes similar to the bristle gene that might be mutated in people with hereditary deafness.
The enzyme is there but doesn't work correctly, suggesting that it might be mutated, says neurologist W. Davis Parker of the University of Virginia School of Medicine in Charlottesville.
The apparent lack of mature adherens junctions in the SF767 cells raised the question as to whether the E-cadherin expressed in these cells might be mutated.
Given the critical role of CBL in normal homeostasis and cancer, we hypothesized that it might be mutated in lung cancers.
The ability of avicins to target degenerate pathways leading to cell death, in a systems manner is likely to make it more effective in a variety of tumor cells which might be mutated for one or the other pathways.
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If homologous or compound heterozygous mutations are found in an FA gene, the subtype of FA is then determined without knowing whether other FA genes might also be mutated in the same patient.
Sometimes a specific gene that might affect mitochondria is known to be mutated, raising the hypothesis that its phenotype is caused by mitochondrial dysfunction.
They can be mutated, crossbred, and cloned.
Surprisingly, only m-type subunit genes were found at the Glu-D3 locus in Ae. tauschii accession AUS18913 [43], indicating that the s-type subunit gene in this material might have been mutated.
We hypothesized that in these males, both copies of the ms(3 k81 gene might have been mutated in male germ cells.
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