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The humanized version of Sphingomab, sonepcizumab/ASONEP (Lpath), has recently completed Phase I clinical trials in cancer, and will be advanced into Phase II safety and efficacy trials, which might be efficacious for controlling tumour growth and metastasis.
I could list literally a dozen more examples, but you get the idea: because we balkanize biomedical research, biomedical-research funding, and pharmaceutical industry drug development according to phenotypically classified diseases, the possibility that a drug that has failed the efficacy test in one disease might be efficacious in a completely different one has not permeated the culture.
With these findings, albumin nanosphere-loading approach might be efficacious to improve the antitumor activity of gemcitabine, and the efficacy is associated with the size of GEM-ANPs.
Neuroactive steroids modulate receptors for neurotransmitters in the brain and thus might be efficacious in the treatment of various diseases of the central nervous system such as schizophrenia.
Although in vitro laboratory data and past reports suggested that heparin might be efficacious in preventing HAE attacks, no controlled study has been reported to examine heparin's efficacy in this regard.
When regional cerebral oxygen desaturation continues during sevoflurane general anesthesia in patients with MMD, it might be efficacious to administer intravenous anesthetics concurrently.
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In patients with fibromyalgia systemic administration of tropisetron (5 mg), reduced pain intensity, tender-point count and improved sleep [19, 20], indicating that 5-HT3-receptor antagonists might even be efficacious in more generalized pain conditions, such as fibromyalgia.
There were no cardiovascular and CNS concerns, suggesting that this drug might also be efficacious in older people.
Interestingly, the TZDs in this study were given by intraocular injection, suggesting that this delivery route of PPAR agonists might also be efficacious in humans [ 37].
As the mechanism of action of SGLT2 inhibitors is different from other agents and completely insulin-independent, the use of these drugs might potentially be efficacious alone or in combination with any other antidiabetic drug, including insulin.
Since AMPK activators such as AICAR or metformin can overcome the inhibitory effects of Ser phosphorylation on replication of the hepatitis C virus [ 30], our present results raise the exciting prospect that AMPK activators such as metformin, which are already used to treat Type 2 diabetes, might also be efficacious in treatment of tumours in which the Akt pathway is hyperactivated.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com