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Most of the mutations may be uninformative "passengers" that come along for the ride, whereas many might be "drivers" that actually cause the unregulated cell proliferation that defines cancer.
Thus, MAGEA mutations might be drivers of tumorigenesis, as has previously been postulated for MAGEE1.
The idea is that some mutations are tissue-specific and might be drivers only in certain kinds of cancers.
Since copy number alterations were more frequent in tumors with less photoreceptorness, genomic alterations might be drivers of tumor progression.
However, the resulting correlation with objective measures of physical activity is similar to that in the present study (5, 15), suggesting that reporting biases in intensity and duration might be drivers of the poor association with accelerometer data.
Similar(55)
The reason might be that drivers were learning how to use them, the group said.
Although it's not clear how well these skills translate to real-life, some earlier work suggests that players might be better drivers.
There is evidence that differentially spliced BARD1 isoforms might be themselves drivers of tumorigenesis.
Some studies went further and empirically investigated the factors that might be important drivers of LOS.
This suggests that E-boxes and RRE repressors might be major drivers of the circadian transcriptome in multiple tissues.
The idea that these proteins might be LMD drivers came from a screen for metastasis genes using transposon-mediated mutagenesis in Patched-deficient mice, which develop medulloblastomas spontaneously [ 19].
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