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This may lead to unspecified genetic interactions, i.e. transactivations, at the site of integration which might be concurrently causative for unspecific Cre expression in many cell types.
The causes for this bias are not easy to discern, but there are several processes that might be concurrently contributing to the observed distribution.
Suppression of autophagy by the PI3K signaling cascade presents a disadvantage for rapidly proliferating tumor cells and leads to the prediction that compensatory mechanisms (like deregulated apoptosis and/or metabolism) might be concurrently activated to prevent the negative implications of defective autophagy on tumor cell survival.
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Computational models have suggested that endpoint variability and deviations from rectilinearity might be minimized concurrently based on a common performance error [6], [7].
Other possible physiological plastic responses such as increases in heart rate and hematogenesis and many other cryptic mechanisms to improve oxygen uptake [24], [25] might be induced concurrently by these environmental signals.
A new protocol for carcinogenesis in rat liver is described in order that confirmatory experiments might be undertaken concurrently.
Although both approaches are still unsatisfactory, since the risk of progression or death remains high, this encouraging evidence of clinical activity suggest they might be used concurrently or sequentially use in an adjuvant setting.
Therefore, the transformation reported in this study might be occurring concurrently in a distributed network of interconnected structures, and not solely performed within the FEF (Paré and Wurtz 2001; Wurtz et al. 2001; Munoz and Schall 2004).
Therefore, our study suggested that compounds targeting PARP and HDAC concurrently might be a practical approach for cancer therapy.
Our study suggested that single agents inhibiting Topo and PARP concurrently might be an alternative for cancer therapy and 11l represented a potential lead compound for development of antitumor agents.
To date, little work has been published on how the D-dimer concentrations might be altered in pregnant women who are concurrently injecting LMWH.
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