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A significant association between a protein variant and cancer only indicates that the change might be causative.
Several treatment modalities went into clinical trials, mainly on the basis of promising effects in rodent models, indicating that immuno-modulation, as evidenced e.g., by cytokine expression profiling or genetic lack/gain of function studies, might be causative.
They reached on average 4 to 7 ng/ml respectively (Figure 2B), suggesting that TSLP might be causative for the AD-like phenotype, as previously reported in humans and mice [22], [23], [24].
Fifty years ago, the idea that viruses might be causative agents of human cancers was controversial.
Additionally, miRNAs that might be causative for the deregulation of genes within the category were detected as described above.
Our data suggest that enhanced proteasomal degradation of low-abundance proteins might be causative for this discrepancy.
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Finally, as the studies are observational, factors correlated with consent to organ donation might not be causative.
The higher rate of emergency procedures in the etomidate group might also be causative for the slight increase of preoperative CK in this group.
Most of our discussion has focused on this issue, and we surmised that associations between some factors and CKD might not be causative.
Thus, it must also be considered that the association between insulin deficiency/hyperglycemia and negative CF outcomes might not be causative, but rather due to other potential mechanisms such as the presence of more advanced pancreatic endocrine dysfunction in the sickest patients.
And so these plaques are causative.
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