These results suggest that myoblasts of the tw mutant might avoid enhanced apoptosis or compensate for a DCG defect by overexpressing cytoskeletal or cell adhesion molecules such as α-spectrin and βPS-integrin.
Due to the inherently high proteotoxic stress in the tumor derived cells, inhibition of HSF1 induction might be a way to counteract the induction of unfolded protein response and avoid apoptosis; a feature that might be necessary for the cell survival.
This function might be critical to allow a transformed cell previously in contact with the basement membrane to grow unchecked and avoid apoptosis in the center of a breast duct.
In cancers, the PI3K pathway is overactive, allowing malignant cells to avoid apoptosis, essentially becoming immortal.
One method to avoid apoptosis would be to maintain a favourable energy balance.
Tumor cells and their precursors have multiple mechanisms to escape or avoid apoptosis that favor survival.
Cancer cells avoid apoptosis and continue to proliferate without any control.
In this way, cancer cells avoid apoptosis and continue to proliferate uncontrollably [ 61].
Following androgen suppression, recurrent prostate carcinomas are able to avoid apoptosis (Koivisto et al, 1997).
Maturing lymphocytes must pass through an intrathymic selective process to avoid apoptosis.
